Anti-inflammatory, Analgesic and Antipyretic Activities of Rubus Ellipticus Smith. Leaf Methanol Extract

Objective: The investigation was undertaken to explore the anti-inflammatory, analgesic and antipyretic activities of Rubus ellipticus. Materials and Methods: The methanolic leaf extract (up to 2000 mg/kg b. wt.) of R. ellipticus was used to observe acute toxicity. Anti-inflammatory activity was evaluated using carrageenan induced paw edema in rats and croton oil induced ear edema in mice. Analgesic activity was evaluated using acetic acid induced writhing and Eddy’s hot plate mediated pain models. Antipyretic activity was investigated by yeast induced pyrexia in rats. Results: The results demonstrated no mortality in the toxicity testing. The extract (200 and 400 mg/kg) showed significant anti-inflammatory, analgesic and antipyretic activities. Both the doses significantly reduced the paw and ear edema compared to indomethacin (20, 10mg/kg) in the anti-inflammatory study, the doses also reduced the writhing responses and increased the latency period significantly in analgesic activity compared to aspirin (100 mg/kg) and morphine (10 mg/kg). The rectal temperatures of the rats were found to be decreased significantly compared to paracetamol (100 mg/ kg). Conclusion: The present study will put forward a scope to develop an effective drug from Rubus ellipticus against inflammatory disorders, as this plant has been used in folk medicine to treat various other ailments.